�ESBATech AG, a preeminent developer of antibody fragment therapeutics,
announced that the company has successfully accomplished its Phase I clinical
study of the company's lead product candidate, ESBA105, in ophthalmic
indications. In April 2008, ESBATech initiated the Phase I study designed to
evaluate the safety, tolerability and pharmacokinetic profile of ESBA105,
when delivered locally via eye drops in healthy volunteers. This run was
conducted as a single and repeated dose escalation sketch in Switzerland.
ESBA105 is a single-chain antibody fragment directed against TNF-alpha, and
it is being developed initially for ophthalmic indications. Several
additional clinical studies are in the
Monday, 8 September 2008
Tuesday, 19 August 2008
Metallica Announce U.S. Tour Dates
Metallica stimulate announced their 'Death Magnetic' U.S. turn, which will run from October 21st of this year, right through until January 31st 2009.
The metal rockers will play 32 shows across four months, joined by support bands Down and The Sword, Lamb of God and Machine Head.
Metallica will predate the dates by cathartic 'Death Magnetic' on September 12th.
October Tour Dates:
Glendale, AZ, Jobing Arena � 21
Albquerque, NM, Tingley Coliseum - 23
Kansas City, MO, Sprint Center - 25
Des Moines, IA, Wells Fargo Arena - 26
November Tour Dates:
Portland, OR, Rose Quarter � 1
Salt Lake City, UT, Energy Solutions Arena - 3
Denver, CO, Pepsi Center - 4
Omaha, NE, Qwest Center - 6
Moline, IL, iWireless Center - 8
Columbus, OH, Schottenstein Center - 9
St. Louis, MO, Scottrade Center - 17
Tulsa, OK BOK, Center - 18
Houston, TX ,Toyota Center - 20
Little Rock, AR, Alltel Arena - 22
New Orleans, LA, New Orleans Arena � 23
December Tour Dates:
Seattle, WA, Key Arena � 1
Vancouver, BC, GM Place - 2
Calgary, AB, Pengrowth Saddledome - 4
Edmonton, AB, Rexall Place - 7
Ontario, CA, Citizens Bank Arena - 8
Fresno, CA, Save Mart Center - 13
San Diego, CA ,Cox Arena - 15
Los Angeles, CA, The Forum - 17
Oakland, CA, Oracle Arena � 20
January 2009 Tour Dates:
Milwaukee, WI, Bradley Center - 12
Detroit, MI Joe Louis Arena - 13
Washington, DC, Verizon Center - 15
Philadelphia, PA ,Wachovia Center - 17
Boston, MA TD, Banknorth Center - 18
Chicago, IL, Allstate Arena - 26
Uniondale, NY, Nassau Coliseum - 29
Newark, NJ, Prudential Center - 31
More info
Saturday, 9 August 2008
Legion Of Doom
Artist: Legion Of Doom
Genre(s):
Metal: Death,Black
Discography:
A Decade Of Darkness and Blood
Year: 2000
Tracks: 14
Kingdom Of Endless Darkness
Year: 1995
Tracks: 7
Tuesday, 1 July 2008
Wisdom In Chains
Artist: Wisdom In Chains
Genre(s):
Rock
Hardcore
Discography:
Die Young
Year: 2007
Tracks: 17
Class War
Year: 2007
Tracks: 17
Self Titled
Year: 2002
Tracks: 11
Rocked the Nation - the final 10
Monday, 23 June 2008
Bob Brown
Artist: Bob Brown
Genre(s):
Techno
Discography:
Series Primary Yellow (FW02)
Year: 1999
Tracks: 4
Series Primary Blue
Year: 1999
Tracks: 4
Rundfunkchor Leipzip, Staatskapelle Dresden
Wednesday, 18 June 2008
Curlew
Artist: Curlew
Genre(s):
Rock
Trance
Discography:
North America
Year: 2002
Tracks: 13
Titolo sconosciuto
Year:
Tracks: 10
Curlew was formed in 1979 by George Cartwright, world Health Organization serves as the group's loss leader, saxophonist and main composer. The other members of Curlew are presently electric guitarists Davey Williams and Chris Cochrane, bassist Ann Rupel and drummer Kenny Wollesen. Although Cartwright is a native Southerner, and brings something of a roadhouse, R&B tittup to his music, Curlew was founded in New York, and has been part of the hip, NYC "business district" scene since its origin. Over the old age, with Cartwright and Williams as the group constants, Curlew has been something of an incubator and showcase for NYC avant malarky talent. Maverick keyboardist Wayne Horvitz played on Curlew's third album, Live in Berlin. Cellist Tom Cora was an early member, and is featured on several Curlew releases; Cora was besides a founding extremity of Skeleton Crew with Fred Frith and has played with such artists as Eugene Chadbourne and John Zorn. Original Curlew drummer Pippin Barnett was a instauration member of the Orthotonics and performed with Cora in the Swiss group Nimal. He was replaced in Curlew by Samm Bennett, world Health Organization was besides a extremity of Third Person, a triad which included Cora. Bennett is besides drummer for the NYC jazz/rock band Chunk. Current bassist Ann Rupel plays in the group No Safety, along with Curlew guitarist Cochrane. And one of Curlew's more data-based releases, the 1993 Beautiful Western Saddle, featured isaac M. Singer Amy Denio and lyrics by poet Paul Haines. This diverse energy has unbroken Curlew on the creative cutting boundary throughout its history, and whatsoever particular version of the band is filled with surprises and dynamic musical interactions. Among Curlew's standout recordings are the no-holds-barred 1986 recording Live in Berlin, 1996's Paradise, and their 1998 release, Mythologic Drop.
Tuesday, 17 June 2008
Brad, Ange splash out on nursery
Brad Pitt and Angelina Jolie have splashed out $US140,000 on a nursery for their twins.
The couple, who are set to welcome two new daughters this month, reportedly hired exclusive Los Angeles baby boutique Petit Tresor to design a luxurious suite for the latest additions to their family.
Items purchased by Brad and Angelina are believed to include two pink crystal chandeliers worth $899 each, $3200 'Versailles-style' cribs and matching $2800 changing tables, organza bassinets worth $800 and $4500 French wardrobes.
he couple also splashed out on cashmere baby toys for their unborn babies.
A team of three Petit Tresor staff were hired to assemble the nursery, according to the New York Daily News newspaper.
Brad and Angelina - who already have three adopted children, six-year-old Maddox, four-year-old Pax and Zahara, three, along with a two-year-old biological daughter Shiloh - are not the only celebrity couple to spend a fortune on a nursery.
Jennifer Lopez and Marc Anthony are said to have ordered a $50,000 nursery from Petit Tresor in preparation for the arrival of their twins in February.
See Also
Aretha Franklin headlining Newport fest
Will perform Aug. 9
NEWPORT, R.I. -- Queen of Soul Aretha Franklin will headline the 2008 JVC Jazz Festival.
Festival organizers say the Grammy winner, whose hits include "Respect," "Chain of Fools" and "I Say a Little Prayer," will perform her gospel-charged soul Aug. 9 at Fort Adams State Park.
Other performers include jazz saxophonists Sonny Rollins and Wayne Shorter, best-selling trumpeter Chris Botti, and pianist and composer Herbie Hancock.
NEWPORT, R.I. -- Queen of Soul Aretha Franklin will headline the 2008 JVC Jazz Festival.
Festival organizers say the Grammy winner, whose hits include "Respect," "Chain of Fools" and "I Say a Little Prayer," will perform her gospel-charged soul Aug. 9 at Fort Adams State Park.
Other performers include jazz saxophonists Sonny Rollins and Wayne Shorter, best-selling trumpeter Chris Botti, and pianist and composer Herbie Hancock.
Buffy The Vampire Slayer - Buffy Fans Study Up
Fans of cult TV show BUFFY THE VAMPIRE SLAYER are studying the series as part of a three-day academic conference at Henderson State University in Arkansas, which began on Friday (06Jun08).
Among the 90 papers discussed as part of philosophy professor Kevin Durand's weekend course are Buffy and Feminism and Hero's Journey, Heroine's Return: Buffy, Eurydice and the Orpheus Myth.
See Also
Michael Uyttebroek
Artist: Michael Uyttebroek
Genre(s):
Ambient
New Age
Discography:
Drums Of Passion
Year: 1993
Tracks: 9
Resonance The Rythms Of Africa
Year:
Tracks: 11
VH1 greenlights 'Scream Queens'
Shaun Escoffery
Artist: Shaun Escoffery
Genre(s):
Dance
Discography:
I Heard it through the Grapevine (Mix)
Year:
Tracks: 1
Diverse year for Tonys
'South Pacific,' 'Osage County' among winners
The spirit of the 62nd annual Tony Awards was captured perfectly early Sunday evening when Bartlett Sher of "South Pacific" was talking to reporters about winning the trophy for best director of a musical just as Lin-Manuel Miranda of "In the Heights" was accepting the prize for best score.
The Sher-led revival of the Rodgers and Hammerstein classic about race and war earned the most awards of any production with seven, perhaps indicating a weak season on Broadway for original work. Yet the four awards for "Heights," including new musical, and the five for the Pulitzer Prize-winning play "August: Osage County" showed that the Main Stem is eager to welcome new voices.
Tracy Letts, author of "August," noted the unusual nature of the evening when he said, "It's surreal, absolutely surreal. A year ago, when I was at my home theater in my home town, the idea of standing here holding this, a year later ... this is absolutely a surreal experience."
Miranda, creator of "Heights" and winner of a Tony for score, said he wasn't trying to shake up Broadway but, in a way, bring it back to its golden days: "It's my job to write the best musical I can," he said. "I'd like to bring popular music and theater music back together. They used to be good friends a long time ago."
The one-named Stew, creator of "Passing Strange" and winner of the Tony for best book of a musical, echoed that thought, but he also seemed to relish the non-conformist of nature of his show, which features a hard-driving, rock 'n' roll score. "It wasn't my intention to write something new," he said. "It was my intention to put music on the stage that people are actually listening to."
Several of the winners in the acting categories also were relative newcomers to Broadway. Mark Rylance, a native of Britain, where he is known as much for his stewardship of the Globe Theatre as he is for his acting, earned a Tony in his Broadway debut for best actor in a play in the revival of "Boeing-Boeing." He proved just how out-there he can be by delivering Louis Jenkins' prose poem "The Back Country" in lieu of an acceptance speech. The audience was by turns amused and bemused but, as Rylance told reporters later, "It has some kind of meaning for me." If he was the only one who saw it, that seemed to be OK by him.
Deanna Dunagan of "August," a 34-year veteran of regional theater, also earned a Tony in her Broadway debut for best actress in a play. "Nothing I did in regional theater could ever prepare me for this," she said. Paulo Szot, a Brazilian known primarily as an opera star, earned best actor in a musical for "South Pacific."
The play started at Chicago's Steppenwolf Theatre; with seven previous productions on the Main Stem, it is not exactly a Broadway novice. But the company has taken pride in being outside the mainstream, both geographically and artistically. Rondi Reed of "August," who earned the Tony for best featured actress in a play and has been with the company since 1979, said Steppenwolf has a yin-yang relationship with New York.
"We had a phase where we were very, 'We don't need New York,' " she said. "I think we were 17 years old at the time. ... It didn't have the allure, but it held all the allure." She also stressed that the company didn't establish a national reputation for itself -- or for such members as John Malkovich and Gary Sinise -- until it brought its first production to Gotham, an Off-Broadway revival of Sam Shepard's "True West."
But there also was plenty of room for Broadway veterans. Patti LuPone earned best actress in a musical for her turn as Mama Rose in the revival of "Gypsy." If there were any doubts who might earn the award for best actress in a musical, they were eradicated 30 minutes into the show, when she delivered the equivalent of a first-round knockout, a bravura performance of "Everything's Coming Up Roses."
It was the second Tony for LuPone, who won for the title role of "Evita" in 1980. She made sure to note the time lapse in her acceptance speech: "It's wonderful to devote yourself to working on the Broadway stage and then every 30 years or so pick up one of these." Her castmate Boyd Gaines won his fourth Tony, for best featured actor in a musical, while Laura Benanti earned her first.
The Tonys are the night where Broadway sings the song of itself, but in some ways the Main Stem was a bit off-key this season. It failed to set new boxoffice records for the first time in three years, largely because of a 19-day strike by its stagehands, and there were no breakout, runaway hit musicals like "Spring Awakening" last year and "Jersey Boys" the year before.
Perhaps the strongest indication of the weak year for musicals is seen in the 11 categories where new and revived work competed against each other. Revivals beat originals nine to two, including seven for "South Pacific." In addition to best revival, it took the Tonys for best actor (Paulo Szot) and director (Sher).
A complete list of winners is available on the next page.
Book-musical: "Passing Strange" (Stew)
Original score (music and/or lyrics): "In the Heights" (Music and lyrics: Lin-Manuel Miranda)
Revival-play: "Boeing-Boeing"
Revival-musical: "South Pacific"
Actor-play: Mark Rylance, "Boeing-Boeing"
Actress-play: Deanna Dunagan, "August: Osage County"
Actor-musical: Paulo Szot, "South Pacific"
Actress-musical: Patti LuPone, "Gypsy"
Featured actor-play: Jim Norton, "The Seafarer"
Featured actress-play: Rondi Reed, "August: Osage County"
Featured actor-musical: Boyd Gaines, "Gypsy"
Featured actress-musical: Laura Benanti, "Gypsy"
Direction-olay: Anna D. Shapiro, "August: Osage County"
Direction-musical: Bartlett Sher, "South Pacific"
Choreography: Andy Blankenbuehler, "In the Heights"
Orchestrations: Alex Lacamoire and Bill Sherman, "In the Heights"
Scenic design-play: Todd Rosenthal, "August: Osage County"
Scenic design-musical: Michael Yeargen, "South Pacific"
Costume design-play: Katrina Lindsay, "Les Liaisons Dangereuses"
Costume design-musical: Catherine Zuber, "South Pacific"
Lighting design-play: Kevin Adams, "The 39 Steps"
Lighting design-musical: Donald Holder, "South Pacific"
Sound design-play: Mic Pool, "The 39 Steps"
Sound design-musical: Scott Lehrer, "South Pacific"
Previously announced:
Regional Theater Tony Award: Chicago Shakespeare Theater
Special Tony Award: Robert Russell Bennett
Lifetime Achievement Award: Stephen Sondheim
The spirit of the 62nd annual Tony Awards was captured perfectly early Sunday evening when Bartlett Sher of "South Pacific" was talking to reporters about winning the trophy for best director of a musical just as Lin-Manuel Miranda of "In the Heights" was accepting the prize for best score.
The Sher-led revival of the Rodgers and Hammerstein classic about race and war earned the most awards of any production with seven, perhaps indicating a weak season on Broadway for original work. Yet the four awards for "Heights," including new musical, and the five for the Pulitzer Prize-winning play "August: Osage County" showed that the Main Stem is eager to welcome new voices.
Tracy Letts, author of "August," noted the unusual nature of the evening when he said, "It's surreal, absolutely surreal. A year ago, when I was at my home theater in my home town, the idea of standing here holding this, a year later ... this is absolutely a surreal experience."
Miranda, creator of "Heights" and winner of a Tony for score, said he wasn't trying to shake up Broadway but, in a way, bring it back to its golden days: "It's my job to write the best musical I can," he said. "I'd like to bring popular music and theater music back together. They used to be good friends a long time ago."
The one-named Stew, creator of "Passing Strange" and winner of the Tony for best book of a musical, echoed that thought, but he also seemed to relish the non-conformist of nature of his show, which features a hard-driving, rock 'n' roll score. "It wasn't my intention to write something new," he said. "It was my intention to put music on the stage that people are actually listening to."
Several of the winners in the acting categories also were relative newcomers to Broadway. Mark Rylance, a native of Britain, where he is known as much for his stewardship of the Globe Theatre as he is for his acting, earned a Tony in his Broadway debut for best actor in a play in the revival of "Boeing-Boeing." He proved just how out-there he can be by delivering Louis Jenkins' prose poem "The Back Country" in lieu of an acceptance speech. The audience was by turns amused and bemused but, as Rylance told reporters later, "It has some kind of meaning for me." If he was the only one who saw it, that seemed to be OK by him.
Deanna Dunagan of "August," a 34-year veteran of regional theater, also earned a Tony in her Broadway debut for best actress in a play. "Nothing I did in regional theater could ever prepare me for this," she said. Paulo Szot, a Brazilian known primarily as an opera star, earned best actor in a musical for "South Pacific."
The play started at Chicago's Steppenwolf Theatre; with seven previous productions on the Main Stem, it is not exactly a Broadway novice. But the company has taken pride in being outside the mainstream, both geographically and artistically. Rondi Reed of "August," who earned the Tony for best featured actress in a play and has been with the company since 1979, said Steppenwolf has a yin-yang relationship with New York.
"We had a phase where we were very, 'We don't need New York,' " she said. "I think we were 17 years old at the time. ... It didn't have the allure, but it held all the allure." She also stressed that the company didn't establish a national reputation for itself -- or for such members as John Malkovich and Gary Sinise -- until it brought its first production to Gotham, an Off-Broadway revival of Sam Shepard's "True West."
But there also was plenty of room for Broadway veterans. Patti LuPone earned best actress in a musical for her turn as Mama Rose in the revival of "Gypsy." If there were any doubts who might earn the award for best actress in a musical, they were eradicated 30 minutes into the show, when she delivered the equivalent of a first-round knockout, a bravura performance of "Everything's Coming Up Roses."
It was the second Tony for LuPone, who won for the title role of "Evita" in 1980. She made sure to note the time lapse in her acceptance speech: "It's wonderful to devote yourself to working on the Broadway stage and then every 30 years or so pick up one of these." Her castmate Boyd Gaines won his fourth Tony, for best featured actor in a musical, while Laura Benanti earned her first.
The Tonys are the night where Broadway sings the song of itself, but in some ways the Main Stem was a bit off-key this season. It failed to set new boxoffice records for the first time in three years, largely because of a 19-day strike by its stagehands, and there were no breakout, runaway hit musicals like "Spring Awakening" last year and "Jersey Boys" the year before.
Perhaps the strongest indication of the weak year for musicals is seen in the 11 categories where new and revived work competed against each other. Revivals beat originals nine to two, including seven for "South Pacific." In addition to best revival, it took the Tonys for best actor (Paulo Szot) and director (Sher).
A complete list of winners is available on the next page.
Book-musical: "Passing Strange" (Stew)
Original score (music and/or lyrics): "In the Heights" (Music and lyrics: Lin-Manuel Miranda)
Revival-play: "Boeing-Boeing"
Revival-musical: "South Pacific"
Actor-play: Mark Rylance, "Boeing-Boeing"
Actress-play: Deanna Dunagan, "August: Osage County"
Actor-musical: Paulo Szot, "South Pacific"
Actress-musical: Patti LuPone, "Gypsy"
Featured actor-play: Jim Norton, "The Seafarer"
Featured actress-play: Rondi Reed, "August: Osage County"
Featured actor-musical: Boyd Gaines, "Gypsy"
Featured actress-musical: Laura Benanti, "Gypsy"
Direction-olay: Anna D. Shapiro, "August: Osage County"
Direction-musical: Bartlett Sher, "South Pacific"
Choreography: Andy Blankenbuehler, "In the Heights"
Orchestrations: Alex Lacamoire and Bill Sherman, "In the Heights"
Scenic design-play: Todd Rosenthal, "August: Osage County"
Scenic design-musical: Michael Yeargen, "South Pacific"
Costume design-play: Katrina Lindsay, "Les Liaisons Dangereuses"
Costume design-musical: Catherine Zuber, "South Pacific"
Lighting design-play: Kevin Adams, "The 39 Steps"
Lighting design-musical: Donald Holder, "South Pacific"
Sound design-play: Mic Pool, "The 39 Steps"
Sound design-musical: Scott Lehrer, "South Pacific"
Previously announced:
Regional Theater Tony Award: Chicago Shakespeare Theater
Special Tony Award: Robert Russell Bennett
Lifetime Achievement Award: Stephen Sondheim
Zooey Deschanel's Musical Ways
While many actors make their music intentions known, Zooey Deschanel is certainly not one of them.
The Happening star released an indie album in March, under the pseudonym She & Him with M. Ward, and tells OK! she had every intention of keeping the whole production on the down-low.
"I released it under a different name and it was out before anyone knew it was me pretty much," Zooey says. "It was under-the-radar when it was released. I made it with M. Ward, and I did all the things that I could do to make sure it was received for the music that it was rather than an actress trying to make an album."
But the 28-year-old was quick to point out that she was never concerned about critical reception, let alone the stigma associated with actors crossing over to music.
"I try not to think too much about what people are going to think of me," she says. "Or I try not to worry too much about it."
A self-proclaimed lifelong musician, Zooey says she might just let her two career paths merge one day in a musical.
"I might, but I like doing my own music, too, because I wrote all the music on my album," she says. "It�s fun to do my own thing."
See Also
Kelsey Grammer back home after heart attack
LOS ANGELES (Reuters) - Former "Cheers" and "Frasier" star Kelsey Grammer was released from a hospital in Hawaii on Wednesday, four days after suffering what was described as a mild heart attack, People magazine reported.
Grammer, 53, is "resting comfortably" at his home on Hawaii's Big Island, People quoted the actor's spokesman as saying.
He had chest pains on Saturday while paddle-boarding with his wife, Camille, and was taken to a hospital, where he was found to have suffered a heart attack.
Grammer was stricken a few weeks after the Fox network canceled his new show, "Back to You," in which he starred as a pompous, womanizing TV news anchor. The series made it for only one season.
Grammer gained fame portraying the sherry-swilling shrink Dr. Frasier Crane for 20 years, initially as a co-star on the NBC comedy hit "Cheers" and then as the star of his own spinoff series.
(Reporting by Dean Goodman; Editing by John O'Callaghan)
Grammer, 53, is "resting comfortably" at his home on Hawaii's Big Island, People quoted the actor's spokesman as saying.
He had chest pains on Saturday while paddle-boarding with his wife, Camille, and was taken to a hospital, where he was found to have suffered a heart attack.
Grammer was stricken a few weeks after the Fox network canceled his new show, "Back to You," in which he starred as a pompous, womanizing TV news anchor. The series made it for only one season.
Grammer gained fame portraying the sherry-swilling shrink Dr. Frasier Crane for 20 years, initially as a co-star on the NBC comedy hit "Cheers" and then as the star of his own spinoff series.
(Reporting by Dean Goodman; Editing by John O'Callaghan)
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